Dane Cook as Dr. Charlie Logan

Jessica Alba as Cam Wexler

Dan Fogler as Dr. Stu Klaminsky

Ellia English as Reba

Lonny Ross as Joe

Troy Gentile as Young Stu

Chelan Simmons as Carol

Mackenzie Mowat as Birthday Girl

Sasha Pieterse as Goth Girl

Caroline Ford as Jennifer

Chiara Zanni as Bride

Benjamin Ayres as Groomsman

Carrie Anne Fleming as Dirty Talker

Yan-Kay Crystal Lowe as Cam's Wedding Friend

Tava Smiley as Woman in Car

Annie Wood as Lara

Kari-Ann Wood as George W. Lover

Victoria Bidewell as Holy Lover

Jodelle Ferland as Lila

Michelle Harrison as Anisha

Steve Bacic as Howard

Georgia Craig as Howard's Wife

Heather Doerksen as Gossipy Woman #1

Michael Teigen as Wedding D.J.

Michelle Andrew as Red Haired Lover

Liam James as Boy in Penguin Habitat

Yasmine Vox as Pleasure

Zara Taylor as Magazine Lover

Eliza Bayne as Wheelbarrow Lover

Susan De West as Shower Lover

Tammy Morris as Contortionist Lover

Viviana Cruise as Thankful Lover

Taayla Markell as Flight Attendant

Connor Price as Young Charlie

Chang Tseng as Karaoke Singer

Lindsay Maxwell as McTitty