50 Cent as Marcus

Joy Bryant as Charlene

Adewale Akinnuoye-Agbaje as Majestic

Omar Benson Miller as Keryl

Terrence Howard as Bama

Viola Davis as Grandma

Ashley Walters as Antwan

Tory Kittles as Justice

Marc John Jefferies as Young Marcus

Sullivan Walker as Grandpa

Bill Duke as Levar

Mpho Koaho as Junebug

Serena Reeder as Katrina

Russell Hornsby as Odell

Vanessa Madden as Marcus' Relative

Joseph Pierre as Uncle Deuce

Ryan Allen as Uncle Ray

Brendan Jeffers as Marcus' Relative

Anastasia Hill as Marcus' Relative

Zainab Musa as Marcus' Relative

Lawrence Bayne as Security Guard

Boyd Banks as Prison Solitary Guard

Lenno Britos as Carlos Delgato

Mykelti Williamson as Charlene's Stepfather (uncredited)

Leon as Slim

Rhyon Nicole Brown as Young Charlene

Paulino Nunes as Detective

Arnold Pinnock as Detective

Frank Pellegrino as Detective Doyle

Bubba as Easy / Coke Dealer

Walter Alza as Raoul

Jer O'Leary as Valdez

Jorge Berrio as Cash Counting Machine Operator

Pedro Miguel Arce as Cash Counting Guard

Mercedez De Castro as Woman

Martha Chaves as Woman

Pedro Salvín as Man

Beatriz Pizano as Rodrigo's Mom

Arlene Duncan as Judge Juvenile Court

Charles Anthony Burks as Car Salesman

Roland Rothchild as Marcus' Lawyer

Ejyp Johnson as Lizard Boot Man (as Curtis 'Ejyp' Johnson)

George Randolph as School Security Guard

Conrad Bergschneider as Prison Guard

Tommy Chang as Store Owner

Vivian Lee as Store Owner's Wife

Ethan James Duff as New Jerseyite

Malik Barnhardt as Gun Salesman

Michael Miller as Dangerous

Don Ritchie as Emergency Room Doctor

Jean Daigle as Prison Corrections Officer

Steve Prempeh as Young Antwan

Cinam Zee as Young Kid

Shane Francis Smith as Young Kid

H. J. Mueller as Young Kid

Andrea Grant as Charlene's Mother

Víctor Gómez as Tito

George Ghali as Landlord

Goûchy Boy as Club Bouncer

Rogue Johnston as Coin Fiend

Michael Colonnese as Raoul's Younger Friend

Mike Santana as Fiend

Benz Antoine as Ray Wilmore

Mantee Murphy as Canary Cook

Quancetia Hamilton as Canary Waitress

Dan Duran as Journalist

Destan Owens as Charlene's Friend

Jerome White as Photographer

Bazil Williams as Teacher

Juliette Nurse as Teacher

Dave Naughton as Prison Tattoo Artist

Lloyd Coke as Majestic Thug

Roger Moore as Majestic Thug

Philip Akin as Reverend

Nigel Henry as Mourner

Dalecia Davis as Neighborhood Kid

Venice Grant as Hot Girl

Linda Boahen as Party Girl

Amber Shana Williams as Party Girl

Jessica Rose Lengyell as Party Girl

Patricia McPherson as Party Girl

Tracy Johnson as Party Girl

Ma’at Zachary as Party Girl (as Keisha 'Ma'at' Zachary)

Christopher Armstrong as Party Boy

Randy Brookes as ND Thug

Luis Fino as Studio Engineer

Pauline Berger as Receptionist

Bruce McFee as Security Guard

Wes Williams as Security Guard

Marlon Smith as Young Majestic Thug

Arnold Dulmus as Young Majestic Thug

Jérome Kern as Young Majestic Thug

Jahvan Caesar as Young Majestic Thug

Jamal Caesar as Young Majestic Thug

Ray H. McKay as Young Majestic Thug

Paul McKay as Young Majestic Thug

Mark McKay as Young Majestic Thug

Tristan Martin as Young Majestic Thug

Renee Miller as Young Majestic Hottie

Keisha Debro as Tammi (as Keisha Brown)

Keleisha Brown as Monique

Paul De La Rosa as Baliff

Angelica Mengana as Reporter

Kenneth Pressman as Diner Paramedic

Barry Moffatt as Diner Paramedic

Joe Boyes as Diner Paramedic

Stefania Vammaro as Gangster's Girlfriend

DeAdra P. Mickel as Check Cashier

Anarosa Peguero as Check Cashier / Drug Addict

Denia Brache as Cashier

Keith P. Scott as NJ Guy (as Keith Schatt)

Richardson Desil as Gun Store Bouncer

Victor of Aquitaine as Mercedes Driver / Drug Buyer (as Victor Fischbarg)

Atif Lanier as Neighborhood Thug

Paul D. Coleman Jr. as Neighborhood Thug

Basil Gibbs as Pelham Hall Security Guard

Kevin Dotcom Brown as Pelham Hall Security Guard (as Kevin Brown)

Rashaad Robert Devore as Subway Man

Balford Gordon as Marcus Crew Guy

Zachary Augustine as Marcus Crew Guy

Lewis Bedford as Marcus Crew Guy

Anwan Ekpo as Marcus Crew Guy

Allan Alexander as Marcus Crew Guy

Marlon J. Hull as Marcus Crew Guy

Jason Moore as Marcus Crew Guy

James Ockimey as Teenage Thug

Vinny Cuevas as Barber Shop Patron (uncredited)

Livingston Beaumont as Principal (uncredited)

Dorly Jean-Louis as Shanelle Club Babe (uncredited)

Mohamed Dione as Street Thug (uncredited)

Michael Yare as Sound Engineer (uncredited)

Jeshua Vargas as Driver (uncredited)

Anthony M. Pizzuto as Protester (uncredited)

Burton Perez as Miguel (uncredited)

Luisa-María Linares as Neighbor (uncredited)

Shareef McIntosh as Extra (uncredited)

Gloria Parks as Dominican Hottie (uncredited)