Jackie Chan as Mr. Han

Ben Wang as Li Fong

Joshua Jackson as Victor Lipani

Sadie Stanley as Mia Lipani

Ming-Na Wen as Dr. Fong

Wyatt Oleff as Alan

Aramis Knight as Conor

Ralph Macchio as Daniel LaRusso

Olivia Yang Avis as Young Girl

Aaron Wang as Young Student

Nicholas Carella as Fat Jerry

Shaunette Renée Wilson as Ms. Morgan

Tim Rozon as O'Shea

Mig Buenacruz as Conor's Sparring Partner

Li Li as Chinese Worker

Henri Forget as Conor's Pal

Noé Poblete as Conor's Pal

Oscar Ge as Bo Fong

Marco Zhang as Young Li

Yusuf A. Ahmed as Thug

Ruben Maldonado as Thug

Jason Hsu as Thug

Marcus Aurelio as Ortiz

Christian Jadah as Social Club Referee

Niko Nikolov as Ortiz's Corner Man

Chance Jones as Hype Man

Mustafa Bulut as Buddha Stevens

Dennis Lafond as Bronx Referee

Anthony Correa Baniaga Jr. as Queens Tornado

Richard Chevolleau as Brooklyn Referee

Canecia Gordon as Subway Worker

Nobuya Shimamoto as Manhattan Referee

Dylan Stanley as Delivery Guy

William Zabka as Johnny Lawrence

Caleb Baker as Student (uncredited)

Jennifer-Lynn Christie as (uncredited)

Mario Dallaire as Train Passenger (uncredited)

David Robitaille as Student / Karate Fan (Uncredited)