Seth Rogen as Dale Denton

James Franco as Saul Silver

Gary Cole as Ted

Danny McBride as Red

Rosie Perez as Carol

Kevin Corrigan as Budlofsky

Craig Robinson as Matheson

Amber Heard as Angie Anderson

Ed Begley Jr. as Robert

Nora Dunn as Shannon

Bobby Lee as Bobby

James Remar as General Bratt

Joe Lo Truglio as Mr. Edwards

Art Napiontek as Clark

Cleo King as Police Liaison Officer

Bill Hader as Private Miller

Jonathan Spencer as Scientist

Dana Lee as Cheung

Ken Jeong as Ken

David C. Cook as Chris Gebert

Howard S. Lefstein as Mark

Connie Sawyer as Faye Belogus

David McDivitt as Cop with Mole

Mae LaBorde as Mrs. Mendelson

Kendall Carly Browne as Old Woman

George Lew as Old Man

John Robert Tramutola as Walt

Adam Crosby as Ack

Andrew Heald as Blake

Jeannetta Arnette as Sandra Danby

Carlos Aleman as Guy in Car

Omar Leyva as Guy in Car #2

Sam Carson as Xerox Secretary

Jack Kehler as Walter - Accountant

Robert Longstreet as Dr. Terrence

Peter Gray Lewis as Thug #1 - Peter

Steve Bannos as Thug #2 - Jared

Eddie Rouse as Thug #5 - Lance

Mark Whigham as Thug #3

Brian Scannell as Thug

Troy Gentile as Troy (uncredited)

Jourdan Lee as Assassin (uncredited)