Oscar Isaac as Nick / Dante

Gal Gadot as Giulietta / Gemma

Gerard Butler as Louie / Pope Bonifacio VIII

John Malkovich as Joe Black

Louis Cancelmi as Lefty / Guido Novello da Polenta

Sabrina Impacciatore as Dr. Susanna Pulice

Franco Nero as Don Lecco

Benjamin Clémentine as Mephistopheles

Paolo Bonacelli as Priest of Alcamo

Martin Scorsese as Isaiah

Al Pacino as Uncle Carmine

Jason Momoa as Rosario

Ibrahim Elouahabi as Young Nick (8)

Gavin Weingarten as Boy With Wagon (11)

Dario Samac as Young Dante (14)

Duke Nicholson as Bar Manager

Denise Capezza as Nick's Ex Girlfriend

Galen Hopper as Nick's Daughter

Lorenzo Zurzolo as Don Lecco (30)

Vincenzo Leto as Don Lecco's Father

Giorgia Arena as Mistress (Don Lecco's Father)

Alessandro De Simone as Young Priest of Alcamo

Gustavo La Volpe as Man from Palermo #1

Giuseppe Cutrullà as Man from Palermo #2

Vincenzo Scuruchi as Man from Palermo #3

Aristide Faggionato as Pilot

Alfonso Venerso as Sedan's Driver

Salvatore La Mantia as Elderly Guard (Don Lecco)

Dora Romano as Old Woman (Don Lecco)

Fabrizio Falanga as Garage Attendant

Saverio Malara as Garage Attendant

Guido Caprino as Guido Cavalcanti

Lolita Chammah as Nursemaid

Audrey Maëlle Bellova Imami as Young Gemma (12)

Lavinia Giaccio as Beatrice (12)

Giovanni D'Addario as Prior #1 (Mayday Fest)

Giovanni Tomassetti as Prior #2 (Mayday Fest)

Stefano Cenci as Cardinal

Giovanni Calcagno as Representative (Florence)

Massimiliano Primo Prigiobbo as Jacopo Alighieri (5)

Niccolò Blokar as Pietro Alighieri (3)

Leandro Iannello as Cangrande (Young)

Andrea Di Stefano as Bartolomeo Della Scala

Pierpaolo Lovino as Library Director (Verona)

Pier Paolo De Minicis as Archivist (Verona)

Alessia Pratolongo as Library Director (Female)

Penny Lane as Receptionist (Ravenna)

Claudio Santamaria as Archivist (Fabriano)

Karina Nazario Farro as Gang Member / Gun Delivery

Simone Buzzi as Egg Head

Howard Thomas Ray as Doctor

Mohamed Zouaoui as Tunisian Bartender

Michelangelo Dalisi as Dying Sailor

Vincenzo Amato as Michele Sindona

David Agranov as David Hanker

Ford Leland as Christie's Consultant (Venice)

Giuseppe Lo Piccolo as Casino Manager

Michele Bevilacqua as Water Taxi Driver

Pappi Corsicato as Butler