Laura Linney as Dr. Karen Ross

Dylan Walsh as Dr. Peter Elliot

Ernie Hudson as Captain Munro Kelly

Tim Curry as Herkermer Homolka

Grant Heslov as Richard

Joe Don Baker as R.B. Travis

Lorene Noh as Amy

Mary Ellen Trainor as Moira

Misty Rosas as Amy the Gorilla

Stuart Pankin as Boyd

Carolyn Seymour as Eleanor Romy

Romy Rosemont as Assistant

James Karen as College President / Elliot's Boss

Bill Pugin as William

Lawrence T. Wrentz as Prof. Arliss Wender

Robert Almodovar as Rudy, TraviCom Security

Kathleen Connors as Sally

Joel Weiss as TraviCom Operator

John Hawkes as Bob Driscoll

Peter Jason as Mr. Janus

Jimmy Buffett as 727 Pilot

James Paradise as Transport Worker #1

William John Murphy as Transport Worker #2

Thom Barry as Samahani

Ayo Adejugbe as African Airport Guard

Kevin Grevioux as Roadblock Officer

Karara Muhoro as Roadblock Soldier

Darnell Suttles as Hospital Interrogator

Michael Chinyamurindi as Claude from Mombasa

Willie Amakye as Lead Porter

Malang as Porter

Jay Speed Forney as Porter

Shelton Mack as Porter

David Mungai as Porter

Anthony Mutune as Porter

Sylvester Mwangi as Porter

Les Robinson as Porter

Nelson Shalita as Porter

E.J. Callahan as DC-3 Pilot

Guy Toley as DC-3 Co-Pilot

Jackson Gitonga as Mizumu Tribesman

Andrew Kamuyu as Mizumu Tribesman

Fidel Bateke as Witch Doctor

Shayna Fox as Amy (voice)

Bruce Campbell as Charles Travis

Taylor Nichols as Jeffrey Weems

Adewale Akinnuoye-Agbaje as Kahega

David Anthony as Gorilla

Brian La Rosa as Gorilla

John Munro Cameron as Gorilla (as John Cameron)

John Alexander Lowe as Gorilla

Jay Caputo as Gorilla

Garon Michael as Gorilla

Peter Elliott as Gorilla

David St. Pierre as Gorilla

Eldon Jackson as Gorilla

Philip Tan as Gorilla

Nicholas Kadi as Gorilla

Christopher 'Critter' Antonucci as Gorilla

Loren Cross as Ghost Tribe Member (Uncredited)

Chris Dupre as Tribe Member (Uncredited)

Delroy Lindo as Captain Wanta (Uncredited)

Joe Pantoliano as Eddie Ventro (Uncredited)

Paul Speaks as Scientist (Uncredited)