Matthew McConaughey as Mud

Reese Witherspoon as Juniper

Tye Sheridan as Ellis

Jacob Lofland as Neckbone

Sam Shepard as Tom

Ray McKinnon as Senior

Sarah Paulson as Mary Lee

Michael Shannon as Galen

Joe Don Baker as King

Paul Sparks as Carver

Bonnie Sturdivant as May Pearl

Stuart Greer as Miller

John Ward Jr. as Galen's Helper

Kristy Barrington as Princess

Johnny Cheek as Kyle

Kenneth Hill as Nelson

Michael Abbott Jr. as James

Earnest McCoy as Man at Budget Inn

Allie Wade as May Pearl's Friend

Douglas Ligon as Motel Clerk

Matt Newcomb as Male Nurse

Mary Alice Jones as Female Nurse

Tate Smalley as Older Kid at Food King

Jimmy Dinwiddie as Bartender

Ryan Jacks as Trooper at Roadblock

Richard Ledbetter as Man on Street (uncredited)