Lana Condor as Ruby Gillman (voice)

Toni Collette as Agatha Gillman (voice)

Annie Murphy as Chelsea Van Der Zee (voice)

Sam Richardson as Uncle Brill (voice)

Liza Koshy as Margo (voice)

Will Forte as Gordon Lighthouse (voice)

Colman Domingo as Arthur Gillman (voice)

Jaboukie Young-White as Connor (voice)

Blue Chapman as Sam Gillman (voice)

Ramona Young as Bliss (voice)

Eduardo Franco as Trevin (voice)

Jane Fonda as Grandmamah (voice)

Nicole Byer as Janice (voice)

Echo Kellum as Doug (voice)

Brianna Arsement as Home Buyer (voice)

Juju Green as Gym Teacher / Coach (voice)

Preston Arsement as Tourist (voice)

Jordan Matter as School Principal (voice)

Ricardo Hurtado as Student #1 / Student #10 (voice)

Randy Thom as Confetti Cannon (voice)

Tiffany Wu as Student #7 (voice)

Merk Nguyen as Student #6 / Student #9 (voice)

Sydney Bell as Student #5 / Student #8 (voice)

Atticus Shaindlin as Topher (voice)

Lynnanne Zager as Phone Voice (voice)

Karen Foster as School Librarian (voice)

Caleb Pierce as Student #3 (voice)

Qalil Ismail as Student #2 (voice)

Suzanne Buirgy as Carol (voice)

Emma Chamberlain as Reporter (voice)