Garry Shandling as Harold Anderson

Annette Bening as Susan Anderson

John Goodman as Roland Jones

Greg Kinnear as Perry Gordon

Ben Kingsley as Graydon

Judy Greer as Rebecca

Danny Zorn as Randy

Harmony Smith as Rita

Richard Jenkins as Don Fisk

Linda Fiorentino as Helen Gordon

Caroline Aaron as Nadine Jones

Janeane Garofalo as Nervous Woman

Octavia Spencer as Baby Nurse

Nora Dunn as Madeline

Cricky Long as Janice

Camryn Manheim as Alison

Ann Cusack as Liz

Jane Lynch as Doreen

Richard Minchenberg as Dr. Weitzman

Drinda Lalumia as Drunken Lady

J.C. MacKenzie as John

Willie Garson as Brett

Marjorie Lovett as Neighbor Woman

Bil Dwyer as Husband

Alexander Lyras as Male AA

Stacey Travis as Woman

Brian Tee as Alien (uncredited)

Sarah Silverman as Woman on plane

Phill Lewis as Other MD

Rick Avery as Airlane Passenger (uncredited)

Tori Bridges as Airport Clerk (uncredited)

James Hunter as Alien Student (uncredited)