Jude Law as Dr. Friedrich Ritter

Vanessa Kirby as Dora Strauch Ritter

Ana de Armas as Eloise Bosquet de Wagner Wehrhorn

Daniel Brühl as Heinz Wittmer

Sydney Sweeney as Margret Wittmer

Felix Kammerer as Rundolph Lorenz

Toby Wallace as Robert Phillipson

Jonathan Tittel as Harry Wittmer

Ignacio Gasparini as Manuel Borja

Richard Roxburgh as Allan Hancock

Paul Gleeson as Stampa

Thiago Moraes as Captain

Nicholas Denton as Ray Elliott

Tim Ross as Hancock's First Officer

Antonio Alvarez as Governor of the Galapagos

Benjamín Gorroño as Governor's Translator