Snoop Dogg as Mac Johnson

Wiz Khalifa as Devin Overstreet

Mike Epps as Mr. Armstrong

Teairra Mari as Ms. Huck

Andy Milonakis as Knees Down

Samantha Cope as Jasmine

Teni Panosian as Ashley

Luenell as Principal Cummings

Paul Iacono as Mahatma Chang Greenberg

Far East Movement as Detention Students

Kendre Berry as Nerdy Chemistry Student / Hemptathalon Smoker 3

Alicia Monet Caldwell as Jubilance

Affion Crockett as Captain Kush

Kelly Pantaleoni as Jenny Billings

Shvona Lavette Chung as M.I.L.F.

Winston James Francis as Massage Parlor Bouncer

YG as Student / Hemptathalon Smoker 2

Tyga as Student

Ty Dolla Sign as Hemptathalon Smoker 1

Nick Pasqual as Nerd

Tiffany Anne Hughes as Hemptathalon Tooted and Pooted Girl

Carla Howe as Masseuse

Melissa Howe as Tattoo Parlor Receptionist

Mystikal as Slow Burn