Lance Crouther as Pootie Tang

JB Smoove as Trucky

Jennifer Coolidge as Ireenie

Reg E. Cathey as Dirty Dee

Robert Vaughn as Dick Lecter

Wanda Sykes as Biggie Shorty

Chris Rock as JB / Radio DJ / Pootie's Father

Mario Joyner as Lacey

Cathy Trien as Stacy

Dave Attell as Frank

Laura Kightlinger as Anchor Woman

Christopher Wynkoop as Sheriff

Rick Shapiro as Shakey

Qiana Drew as Singing Lady

Lorria Richards as Singing Lady

J.D. Williams as Froggy

Tara Jeffers as Solo Girl Singer

Cole Hawkins as Little Pootie

Andy Richter as Record Executive

Kristen Bell as Record Executive's Daughter

Ray Wills as Board Director

Robert Trumbull as Board Director

Jim Earl as Eddie

David Cross as Dennis

Chuck Jeffreys as Bad Bitty

Tammy Faye Starlite as Dirty Dee Girl

Jodi Michelle Pynn as Dirty Dee Girl

Stacy Renae as Sidewalk Girl

Alem Brhan Sapp as Guitar Player

Joseph Dolphin as Greasy

Todd Barry as Greasy

Keesha Sharp as Party Girl

Greg Hahn as Prison Guard

Jon Glaser as Recording Engineer (as John Glaser)

William Stephenson as Fast Food Cook

Robin Montague as Screaming Woman

Devon Malik Beckford as Sweet Little Boy

Missy Elliott as Diva

Bryan Hearne as Little Trucky

Ebony Jo-Ann as Pootie's Mother

Bob Costas as Bob Costas

Conan O'Brien as Conan O’Brien (uncredited)

Brian Donahue as Pootie Impostor (uncredited)

Michelle Robinson as Jilted Woman

Keenan Shimizu as Big Father

Linda Murrell as Burger Joint Reporter

Michael Broughton as Bad Bitty Goon

Tony Rhune as Bad Bitty Goon

Andy Duppin as Dirty Dee Goon

David S. Lomax as Dirty Dee Goon

Bob Colletti as Gorilla

Lanette Ware as Flashback Woman (uncredited)

Brian Smyj as Pootie Impersonator (uncredited)

Diandra Newlin as Pork Chunks Girl (uncredited)

Cecelia Antoinette as Party Girl (uncredited)