Lance Crouther as Pootie Tang

Jennifer Coolidge as Ireenie

JB Smoove as Trucky

Reg E. Cathey as Dirty Dee

Robert Vaughn as Dick Lecter

Wanda Sykes as Biggie Shorty

Chris Rock as JB / Radio DJ / Pootie's Father

Mario Joyner as Lacey

Cathy Trien as Stacy

Laura Kightlinger as Anchor Woman

Dave Attell as Frank

Rick Shapiro as Shakey

Christopher Wynkoop as Sheriff

J.D. Williams as Froggy

Missy Elliott as Diva

David Cross as Dennis

Qiana Drew as Singing Lady

Lorria Richards as Singing Lady

Andy Richter as Record Executive

Kristen Bell as Record Executive's Daughter

Cole Hawkins as Little Pootie

Tara Jeffers as Solo Girl Singer

Conan O'Brien as Conan O’Brien (uncredited)

Ebony Jo-Ann as Pootie's Mother

Bob Costas as Bob Costas

Brian Donahue as Pootie Impostor (uncredited)

Keesha Sharp as Party Girl