Lea Thompson as Beverly Switzler

Jeffrey Jones as Dr. Walter Jenning

Tim Robbins as Phil Blumburtt

Ed Gale as Howard T. Duck

Chip Zien as Howard T. Duck (voice)

Tim Rose as Howard T. Duck

Steve Sleap as Howard T. Duck

Peter Baird as Howard T. Duck

Mary Wells as Howard T. Duck

Lisa Sturz as Howard T. Duck

Jordan Prentice as Howard T. Duck

Paul Guilfoyle as Lieutenant Welker

Liz Sagal as Ronette

Dominique Davalos as Cal

Holly Robinson Peete as K.C.

Tommy Swerdlow as Ginger Moss

Richard Edson as Ritchie

Miles Chapin as Carter

Richard McGonagle as First Cop

Virginia Capers as Coramae

Debbie Lee Carrington as Additional Ducks (voice)

Jorli McLain as Waitress

Miguel Sandoval as Club Owner

Sheldon Feldner as Hot Tub Spa Owner

Lee Anthony as Grossbach

Paul Comi as Dr. Chapin

Maureen Coyne as Teacher

James Lashly as State Trooper

Tom Parker as Steve Kanelli

Ed Holmes as TV Duck Hunter

David Paymer as Larry, Scientist

William Hall as Hanson

Denny Delk as Sergeant

Martin Ganapoler as First Trucker

Tom Rayhall as Second Trucker

Gary Littlejohn as Third Trucker

Thomas Dolby as Bartender in Rock Club

Kristopher Logan as Punk

Reed Kirk Rahlmann as Bender

John Fleck as Pimples

William McCoy as Skin Head

Steven Kravitz as Lover Boy

Anne Tofflemire as Lover Girl

Marcia Banks as Mama Biker

Nancy Fish as Bag Lady

Monty Hoffman as Club Bouncer

Ted Kurtz as Kirby

Wood Moy as Chef

Wanda McCaddon as Hostess

James Brady as First Tour Guide

Carol McElheney as Screaming Woman

Jeanne Lauren as Bear

Richard Kiley as The Cosmos (voice)

Mel Blanc as Daffy Duck (voice) (archive sound)