Maya Hawke as Flannery O'Connor

Laura Linney as Regina O'Connor

Philip Ettinger as Robert "Cal" Lowell

Rafael Casal as O.E. Parker

Willa Fitzgerald as Elizabeth Hardwick

Liam Neeson as Father Flynn

David Towne as Buzz Cut

Steve Zahn as Tom T. Shiftlet

Cooper Hoffman as Manley Pointer

Nikola V. Pajic as Thomas

Caisey Cole as Jean

Wilson Conkwright as Walter

Christine Dye as Duchess

LaKeta Caston as Sullen Woman

George Sheanshang as Claud Turpin

Alessandro Nivola as John Selby

Matthew Kimbrough as Doctor Block

Demetrius T. Wheeler as Emmanuel

Mehmet Can Aksoy as Jesus

Daniel R. Hill as Tattoo Artist

Jan Falk as Mrs. Freeman

Connor Lysholm as Ping Pong Opponent

Owen Phillips as Diner Boy

Chaney Morrow as Scoundrel

Amelya Hensley as Marriage License Woman

Vincent D'Onofrio as Sheriff

Kevin Downes as Fighting Couple Man

Brittany Gillstrap as Piano Player

Father Matthew Hardesty as Priest

Levon Hawke as Convict

Joseph Perkins as One Armed Man

Bill Lobley as Trailer VO

Ty Jones as Additional VO

Jessie Clark as Church Choir

Christianne Maserson as Church Choir

Mary Parkinson as Church Choir

Regina Pimental as Church Choir

Jacob Watson as Bus Passenger (uncredited)