Rick Moranis as Seymour Krelborn

Ellen Greene as Audrey

Vincent Gardenia as Mushnik

Levi Stubbs as Audrey II (voice)

Steve Martin as Orin Scrivello, D.D.S.

Tichina Arnold as Crystal

Michelle Weeks as Ronnette

Tisha Campbell as Chiffon

Jim Belushi as Patrick Martin

John Candy as Wink Wilkinson

Christopher Guest as The First Customer

Bill Murray as Arthur Denton

Stan Jones as Narrator (voice)

Bertice Reading as 'Downtown' Old Woman

Ed Wiley as 'Downtown' Bum #1

Alan Tilvern as 'Downtown' Bum #2

John Scott Martin as 'Downtown' Bum #3

Vincent Wong as Chinese Florist

Mak Wilson as Doo-Wop Street Singer

Danny Cunningham as Doo-Wop Street Singer

Danny John-Jules as Doo-Wop Street Singer

Gary Palmer as Doo-Wop Street Singer

Paul Swaby as Doo-Wop Street Singer

Mildred Shay as Second Customer

Melissa Wiltsie as Third Customer

Kevin Scott as Fourth Customer

Barbara Rosenblat as Fifth Customer

Adeen Fogle as Radio Station Assistant

Kelly Huntley as Audrey & Seymour's Kid

Paul Reynolds as Audrey & Seymour's Kid

Miriam Margolyes as Dental Nurse

Abbie Dabner as Boy Patient

Francis Dux as Second Patient

Peter Whitman as Patient on Ceiling

Heather Henson as Girl Patient

Judith Morse as Girl's Mother

Bob Sherman as Agent

Doreen Hermitage as 'Life' Magazine Lady

Kerry Shale as Her Assistant

Robert Arden as Network Exec #1

Stephen Hoye as Network Exec #2

Bob Sessions as Network Exec #3

Michael Shannon as Television Reporter

Jill Goldston as Frantic Shopper (uncredited)