Carlos Alazraqui as Winslow (voice)

Jim Cummings as Cat (voice)

Tom Kenny as Dog / Cliff (voice)

Jane Krakowski as CatDog's Mother / Pussycat Catfield (voice)

Dwight Schultz as Eddie (voice)

Billy Bob Thornton as Hound Dog McDog / CatDog's Step-father (voice)

Frank Welker as Bessie the Sea Monster (voice)

Maria Bamford as Shriek Dubois (voice)

Billy West as Rancid Rabbit (voice)

Nika Futterman as Lola (voice)