Jeff Goldblum as Professor Brody

Elizabeth Perkins as Mrs. Brody

Alexander Pollock as Scotty Brody

Miriam Margolyes as Sophie the Castle Maid

Tobey Maguire as Lou the Beagle (voice)

Alec Baldwin as Butch (voice)

Sean Hayes as Mr. Tinkles (voice)

Susan Sarandon as Ivy (voice)

Joe Pantoliano as Peek (voice)

Michael Clarke Duncan as Sam (voice)

Jon Lovitz as Calico (voice)

Charlton Heston as The Mastiff (voice)

Glenn Ficarra as Russian Blue (voice)

Billy West as Ninja Cat #1 (voice)

John Michael Higgins as Ginger Kitten (voice)

Richard Steven Horvitz as Puppy in Barn (voice)

Frank Welker as Buddy (voice)

Frank C. Turner as The Farmer

Lauren K. Robek as Pie Mom (as Kirsten Robek)

Mar Andersons as Guard at Gate

Gillian Barber as Factory Receptionist

Carol Ann Susi as Sophie's Sister

Randi Kaplan as Sophie's Sister

Mary Bogue as Sophie's Sister

Alvin Sanders as Mason Employee

Mark Schooley as Mason Employee

Lou Bollo as Worker

Scott Nicholson as Worker

Trish Schill as Worker

Babe Dolan as Wife Passenger

Reg Glass as Truck Driver (as Reginald Glass)

Charles Andre as Truck Driver

Peggy Logan as Nurse

Alicia Michelle as Jogger

Pamela Perry as Yorkie Dog Owner

Victor Wilson as Doberman Drill Sergeant (voice)

Salome Jens as Collie at HQ (voice)

Danny Mann as Ninja Cat (voice)

Billy West as Ninja Cat (voice)

Paul Pape as Wolf Blitzer (voice)

Myron Natwick as Mr. Mason

Doris Chillcott as Mrs. Calvert