Penelope Ann Miller as Dr. Margo Green

Tom Sizemore as Lt. Vincent D'Agosta

Linda Hunt as Dr. Ann Cuthbert

James Whitmore as Dr. Albert Frock

Clayton Rohner as Det. Hollingsworth

Chi Muoi Lo as Dr. Greg Lee

Thomas Ryan as Tom Parkinson

Robert Lesser as Mayor Robert Owen

Diane Robin as The Mayor's Wife

Lewis van Bergen as John Whitney

Constance Towers as Mrs. Harriet Blaisedale

Francis X. McCarthy as Mr. George Blaisedale

Audra Lindley as Dr. Matilda Zwiezic

John Kapelos as McNally

Tico Wells as Bailey

Mike Bacarella as Bradley

Gene Davis as Martini

John DiSanti as Guard Wootton

David Proval as Guard Johnson

Jophery C. Brown as Guard Frederick Ford

Don Harvey as Spota

Ronald Joshua Scott as Josh

Dave Graubart as Eugene

Santos Morales as Capt. Borne

Ralph Seymour as Sergeant

Lyn Alicia Henderson as Perri Masai

Brian Steele as Kothoga

Amanda Ingber as Donna

Montrose Hagins as Chanting Woman (as Montrose Hughes)

LaDonna Tittle as Teacher

Eddie Jemison as Museum Worker

David Hollander as Charlie

Katharine Mitchell as Police Officer

Kurt Naebig as Police Officer

Ken Magee as Coroner's Assistant

Aaron Lustig as Dr. Brown

Kent George as Student

Ron Cummins as Dr. Gross

Mark Lake as SWAT Team Guy

Ned Schmidtke as Capt. Martin

Vincent Hammond as Kothoga

Gary A. Hecker as Kothoga (voice)

Ramon Ramierez as Tribal Dancer

Martin S. Tellez as Tribal Dancer

Craig Hosking as Helicopter Pilot

Dana Kristen Vahle as Helicopter Pilot

Dick Warlock as Policeman (uncredited)