Ashley Olsen as Jane Ryan

Mary-Kate Olsen as Roxy Ryan

Eugene Levy as Max Lomax

Andy Richter as Bennie Bang

Riley Smith as Jim, The Bike Messenger

Jared Padalecki as Trey Lipton

Drew Pinsky as Dr. Ryan

Darrell Hammond as Hudson McGill

Andrea Martin as Senator Anne Lipton

Alannah Ong as Ma Bang

Bob Saget as Himself

Jack Osbourne as Justin

Mary Bond Davis as Big Shirl

Neil Crone as Officer Strauss

Sébastien Lefebvre as Simple Plan

David Desrosiers as Simple Plan

Pierre Bouvier as Simple Plan

Chuck Comeau as Simple Plan

Jeff Stinco as Simple Plan

Boyd Banks as Ticket Window Guy

Frank Welker as Reinaldo Vocal Effects (voice)

H. Jon Benjamin as I Love NY Vendor

Jo Chim as Ma Bang's Assistant

Joey Klein as Truant at Pool

Jonathan Wilson as Train Conductor

Silver Kim as Asian Guy with Chip

The Naked Cowboy as Self

Oluniké Adeliyi as Big Shirl's Beautician

Lindsay Leese as Customer at Ma Bang's

Frank Bonsangue as Con Ed Supervisor

Kent Staines as Doorman

Damon D'Oliveira as News Broadcaster

Eric Woolfe as Male Nurse

Warren Belle as Mickey the Cab Driver

Kathleen Laskey as Steffi Brooger

John Hemphill as Tim Brooger

Jamila Fleming as House of Bling Customer