Christopher Guest as Nigel Tufnel

Michael McKean as David St. Hubbins

Harry Shearer as Derek Smalls

Rob Reiner as Marty DiBergi

June Chadwick as Jeanine Pettibone

Bruno Kirby as Tommy Pischedda

Ed Begley Jr. as John 'Stumpy' Pepys

Fran Drescher as Bobbi Flekman

Dana Carvey as Mime Waiter

Sandy Helberg as Angelo DiMentibelio

Billy Crystal as Morty the Mime

Paul Benedict as Tucker 'Smitty' Brown

Howard Hesseman as Terry Ladd

Russ Kunkel as Eric 'Stumpy Joe' Childs

Joyce Hyser as Belinda

Paul Shaffer as Artie Fufkin

Archie Hahn as Room Service Guy

Fred Willard as Colonel on Military Base

Anjelica Huston as Polly Deutsch

Brinke Stevens as Girlfriend (uncredited)

Patrick Macnee as Sir Denis Eton-Hogg

Tony Hendra as Ian Faith

R.J. Parnell as Mick Shrimpton

David Kaff as Viv Savage

Danny Kortchmar as Ronnie Pudding

Julie Payne as Mime Waitress

Zane Buzby as Rolling Stone Reporter

Paul Shortino as Duke Fame

Lara Cody as Fame Groupie

Andrew J. Lederer as Student Promoter

Victory Tischler-Blue as Cindy

Gloria Gifford as Airport Security Officer

Charles Levin as Disc 'n' Dat Manager

Donald Kendrick as Background Vocalist

Wonderful Smith as Backstage Maintenance Worker

Kimberly Stringer as Heavy Metal Fan

Chazz Dominguez as Heavy Metal Fan

Shari Hall as Heavy Metal Fan

Jean Cromie as Ethereal Fan

Patrick Maher as New York M.C.

Memo Vera as Bartender

Robin Menken as Angelo's Associate

Jennifer Child as Limo Groupie

J.J. Barry as Rack Jobber

George McDaniel as Southern Rock Promoter

Anne Churchill as Reba

Cherie Darr as Fame Groupie

Diana Duncan as 'Jamboree Bop' Dancer

Gina Marie Pitrello as 'Jamboree Bop' Dancer

Gina Jourard as 'Jamboree Bop' Dancer (as Gina Marie Pitrello)