Audrey Tautou as Thérèse Desqueyroux

Gilles Lellouche as Bernard Desqueyroux

Anaïs Demoustier as Anne

Stanley Weber as Jean Azevedo

Yves Jacques as L'avocat de Thérèse Desqueyroux

Francis Perrin as Monsieur Larroque

Isabelle Sadoyan as Tante Clara

Catherine Arditi as Madame de la Trave

Jérôme Thibault as Deguilhem

Max Morel as Balion

Françoise Goubert as Balionte

Jean-Claude Calon as Monsieur de la Trave

Alba Gaïa Bellugi as Thérèse Larroque à 15 ans

Matilda Marty as Anne de la Trave à 15 ans

Bernard Lebeau as Ponte Bordeaux

Frédéric Kneip as Le juge

Jack Delbalat as Le pharmacien Darquey

Gérard Bayle as Pedemay