Rick Moranis as Wayne Szalinski

Marcia Strassman as Diane Szalinski

Robert Oliveri as Nick Szalinski

Daniel Shalikar as Adam Szalinski

Joshua Shalikar as Adam Szalinski

Lloyd Bridges as Clifford Sterling

John Shea as Hendrickson

Keri Russell as Mandy

Ron Canada as Marshall Brooks

Amy O'Neill as Amy Szalinski

Michael Milhoan as Capt. Ed Myerson

Gregory Sierra as Terence Wheeler

Leslie Neale as Constance Winters

Julia Sweeney as Nosey Neighbor

Linda Carlson as Nosey Neighbor

Lisa Mende as Lab Technician

John Paragon as Lab Technician

Kenneth Tobey as Smitty

Bill Moseley as Federal Marshall

Edward S. Feldman as Las Vegas Couple (as Ed Feldman)

Suzanne Kent as Las Vegas Couple

Alex Daniels as Uncle Yanosh

Robert Jaffe as Motorcycle Officer

Ron Lawrence as Motorcycle Officer

John Hora as Helicopter Observer

Mary Ellen Moore as Police Woman

Randy Swallow as Vegas Reporter

Pamela Cederquist as Vegas Reporter

James M. Lauten as Vegas Reporter

Shannon M. Steger as Nevada Militia

Minori Goto as Japanese Tourist

Mamoru Kanal as Japanese Tourist

Gregory McCurdy as Police Officer

David Scates as Rock Fan in Crowd

Marion Palmer as Hard Rock Reporter

Kathy Pastor as Hard Rock Hostess

Bill Loska as Highway Patrol Officer

Richard Simmons as Self - (Archive Footage)

Sammy as Quark the Dog (uncredited)