Anthony Hopkins as Alfred Hitchcock

Helen Mirren as Alma Reville

Scarlett Johansson as Janet Leigh

Danny Huston as Whitfield Cook

Toni Collette as Peggy Robertson

Michael Stuhlbarg as Lew Wasserman

Michael Wincott as Ed Gein

Jessica Biel as Vera Miles

James D'Arcy as Anthony Perkins

Richard Portnow as Barney Balaban

Kurtwood Smith as Geoffrey Shurlock

Ralph Macchio as Joseph Stefano

Kai Lennox as Hilton Green

Tara Summers as Rita Riggs

Wallace Langham as Saul Bass

Paul Shackman as Bernard Herrmann

Currie Graham as PR Flack

Spencer Garrett as George Tomasini

Terry Rhoads as Jack Russell

Tom Virtue as NY Theater Manager

Karina Deyko as Pretty Secretary

Steven Lee Allen as Crew Member

Richard Chassler as Martin Balsam

Frank Collison as Henry Gein

Melinda Chilton as Margo (Perkins' Double)

Mary Anne McGarry as Hedda Hopper Type

Jon Abrahams as Reporter #1

Gil McKinney as Reporter #2

Emma Jacobs as Blonde Fan

Spencer Leigh as Nunzio

Sean MacPherson as Waiter

Gerald V. Casale as David Kirkpatrick

Tara Arroyave as Woman Waiting in Line

Josh Yeo as John Gavin

Judith Hoag as Lillian

Danielle Burgio as Dead Woman in Tub

John Lacy as First Guard

Howard Gibson as Party Guest

Josette Prevost as Party Guest

Lauren Stewart as Party Guest

Jaehne Moebius as Party Guest

Ana Matallana as Female Prop Assistant

Lindsey Ginter as Male Prop Master

Brett Chapin as Hitchcock Fan

Paul Henderson as Beach Walker

Kay Henderson as Beach Walker

Lisa Marie Boiko as Film Crew

Richard Burns as Film Crew

Meredith Claire as Film Crew

Alexia DuBasso as Film Crew

Jonn Faircrest as Film Crew

Gina Fricchione as Film Crew

James R. Gavio as Film Crew

James Henderson as Film Crew

Bruce Holman as Film Crew

Dion W.H. Holt as Film Crew

Jeremiah Hundley as Film Crew

Michael Kurtz as Film Crew

Joseph Martino as Film Crew

Jeremy S. Miles as Film Crew

Jon Renfield as Film Crew

Linda Sans as Film Crew

James Tappan as Film Crew

Jon Thibault as Film Crew

Sebastian Vale as Film Crew

Jason Wingo as Film Crew

Cynthia Youngblood as Film Crew

Bill Blair as Premier Theatre Guest (uncredited)