Charlton Heston as Robert Neville

Anthony Zerbe as Matthias

Rosalind Cash as Lisa

Paul Koslo as Dutch

Eric Laneuville as Richie

Lincoln Kilpatrick as Zachary

Anna Aries as Woman in Cemetery Crypt

Brian Tochi as Tommy

DeVeren Bookwalter as Family Member

John Dierkes as Family Member

Jill Giraldi as Little Girl

Monika Henreid as Family Member

Linda Redfearn as Family Member

Forrest Wood as Family Member

Steve Goldstein as Last Boy (uncredited)