Hugh Grant as Dr. Guy Luthan

Gene Hackman as Dr. Lawrence Myrick

Sarah Jessica Parker as Jodie Trammel

David Morse as Frank Hare

Bill Nunn as Burke

Paul Guilfoyle as Dr. Jeffrey Manko

Debra Monk as Dr. Judith Gruszynski

John Toles-Bey as Bobby

Peter Appel as Det. Stone

Shaun Austin-Olsen as Claude Minkins

André De Shields as Teddy Dolson

J.K. Simmons as Dr. Mingus

Diana Zimmer as Helen

Nancy Beatty as Ruth Myrick

Gerry Becker as Dr. Gene Spitelli

Gene Ruffini as Izzy

Bill MacDonald as Det. Stone's Partner

Garnet Harding as E.R. Doctor

Simon Reynolds as E.R. Doctor

Derwin Jordan as E.R. Doctor

Tara Rosling as E.R. Doctor

Martin Roach as E.R. Doctor

Bernard Browne as E.R. Doctor

Sanjay Talwar as E.R. Doctor

Christina Collins as E.R. Nurse

Arlene Duncan as E.R. Nurse

Cheryl Swarts as E.R. Nurse

Peter Maloney as Mr. Randall

Johnie Chase as Cop

Noam Jenkins as Criminal

Larissa Laskin as Myrick's Daughter

Phallon Carpino as Granddaughter

Ross Petty as Dr. Garlock

Todd Stewart as Shelter Supervisor

Lawrence Arancio as Medical Examiner

Vincent Marino as Janitor

Marcia DeBonis as Pam

John Ventimiglia as Det. Manning

John Heffernan as Cartman

Raynor Scheine as Half-Mole

John Trudell as Tony

Nelson Vasquez as Skicap

Vincent Laresca as Patches

Denis Akiyama as Prof. Asakura

Kim Roberts as Home Nurse

Gerry Quigley as Party Guest

Teresa Yenque as Neighbor

Chris Edwards as Uniformed Cop

David Eisner as Guy's Lawyer

Dana Stevens as Prosecutor

Michael J. Reynolds as Judge

David Cronenberg as Hospital Lawyer

Jackie Richardson as Triphase Nurse

Marium Carvell as Triphase Nurse

Marilyn McDonald as Mole Lady

Desi Moreno as Toll Collector (uncredited)