Mark Ruffalo as Ned Weeks

Matt Bomer as Felix Turner

Taylor Kitsch as Bruce Niles

Jim Parsons as Tommy Boatwright

Alfred Molina as Ben Weeks

Julia Roberts as Dr. Emma Brookner

Joe Mantello as Mickey Marcus

BD Wong as Buzzy

Jonathan Groff as Craig

Stephen Spinella as Sanford

Finn Wittrock as Albert

Denis O'Hare as Hiram Keebler

Corey Stoll as John Bruno

Frank De Julio as Nick

William DeMeritt as Nino

Sean Meehan as Morton

Jill Melanie Wirth as Receptionist

Adam B. Shapiro as Bella

John Mainieri as John

Will Bradley as Mario

Chris Sullivan as Mike the Tech

Corey Brill as Henry

Frank Fortunato as City Hall Guard

Armand Schultz as Dick Lombardo

Rebecca Watson as Sarabeth Clare

Gregory Adair as Malcom Murphy

Danielle Ferland as Estelle

Joe Lanza as TV Reporter

Francois Battiste as Cameraman

Wenne Alton Davis as Gloria

Richard Prioleau as Phil

Patrick Woodall as Grady

Brett Glazer as Lenny

Rob Tunstall as Man on the Subway

Irena Bakovic as Stewardess

Catherine Chadwick as Albert's Mother

Eden Marryshow as Orderly

Scott Johnsen as Undertaker

Remy Auberjonois as Examining Doctor