Bing Crosby as Dr. James 'Jim' Pearson

Joan Caulfield as Trudy Mason

Barry Fitzgerald as Dr. Joseph McRory

Wanda Hendrix as Emily Walters

Frank Faylen as Bill Walters

Elizabeth Patterson as Mrs. Gilley

Robert Shayne as Roy Chesley

Larry Young as Dr. Ronnie Jenks

Percy Kilbride as Nat Dorkas

Charles Dingle as Charles 'C.J.' Chesley

Don Beddoe as Mort Elkins

Thurston Hall as Congressman Beeker (uncredited)

Lillian Bronson as Miss Lennek

Mary Field as Secretary

Paul Stanton as Mr. Daniels

Patrick McVey as Ed Chanock

Richard M. Norman as

Frank Ferguson as Crane (uncredited)

Margaret Field as Photo of Cousin Hattie (uncredited)

Milton Kibbee as Ben - Bus Driver (uncredited)

Charles Middleton as Farmer Pinkett (uncredited)

Clarence Muse as Clarence, Train Waiter (uncredited)