Colin Farrell as Captain Smith

Q'orianka Kilcher as Pocahontas

Christopher Plummer as Captain Newport

Christian Bale as John Rolfe

August Schellenberg as Powhatan

Wes Studi as Opechancanough

David Thewlis as Wingfield

Yorick van Wageningen as Captain Argall

Raoul Max Trujillo as Tomocomo

Michael Greyeyes as Rupwew

Kalani Queypo as Parahunt

Ben Mendelsohn as Ben

Noah Taylor as Selway

Brían F. O'Byrne as Lewes

Ben Chaplin as Robinson

Jamie Harris as Emery

Janine Duvitski as Mary

Eddie Marsan as Eddie

Joe Inscoe as Ackley

Jake Curran as James

John Savage as Savage

Thomas Clair as Patawomeck

Alex Rice as Patowomeck's Wife

Irene Bedard as Pocahontas' Mother

Ford Flannagan as Winthrop

Bev Appleton as Small

Billy Merasty as Kiskiak

Jonathan Pryce as King James

Alexandra W.B. Malick as Queen Anne

Jasper Britton as Laureate

Myrton Running Wolf as Tockwhogh

E. Danny Murphy as Bosun

Jonathan Gonitel as Thomas - 4 Yrs

Brian Merrick as Assailant

Chris Nelson as Chris

Colin Cox as Cox

Will Wallace as William Sentry

Steven Dawn as Goldsmith

Rulan Tangen as Two Moons

Jesse Borrego as Pepaschicher

Todd Wallace as Sailor

Kirk Acevedo as Sentry

Nive Nielsen as Inuit Woman

Tayla Kean as Cabin Boy 1

Thomas Steven McDonagh as Cabin Boy 2

James McDonagh as Cabin Boy 3

Gary Sundown as Messenger

Michael Goodwin as Helmsman

Sam Stevenson as Young Lady

Maria Pastel as Rosalind

Raynor Scheine as Raynor

Jeremy Radin as Jeremy

Matthew Yeung as Shaman

Gregory Labenz as Sentry 2

Miraida Rios as (voice actor)