Geena Davis as Samantha Caine / Charly Baltimore

Samuel L. Jackson as Mitch Henessey

Yvonne Zima as Caitlin Caine

Craig Bierko as Timothy

Tom Amandes as Hal

Brian Cox as Dr. Nathan Waldman

Patrick Malahide as Leland Perkins

David Morse as Luke / Daedalus

Joseph McKenna as One-Eyed Jack

Melina Kanakaredes as Trin

Dan Warry-Smith as Raymond

Kristen Bone as Girl #1

Jennifer Pisana as Girl #2

Rex Linn as Man in Bed

Alan North as Earl

Edwin Hodge as Todd Henessey

Bill MacDonald as Hostage Agent

Gladys O'Connor as Alice

Frank Moore as Surveillance Man

G. D. Spradlin as President

Graham McPherson as CIA Director

Sharon Washington as Fran Henessey

Judah Katz as Harry (Perkin's Aide)

Robert Thomas as Alley Agent

John Stead as Deer Lick Sentry

Marc Cohen as Teenage Burnout #1

Chad Donella as Teenage Burnout #2

Deborah Kirshenbaum as Operator

Shawn Doyle as Donlevy Bum Cop

Ken Ryan as News Anchor

Susan Henley as Church Mother

Craig Eldridge as Crime Scene Reporter

Charles A. Tamburro as Helicopter Pilot

Larry King as Self

Gerry Bamman as CIA Man (uncredited)

Ivar Brogger as Intelligence Analyst Jack Wadsworth (uncredited)

Michael G. Brown as Assassin (uncredited)

Reginald Doresa as Bar Patron (uncredited)

Paul Essiembre as Press Aide (uncredited)

Erin Gooderham as Church Lady (uncredited)

Michael K. Jones as Bum Cop #2 (uncredited)

Carrie Loring as Caroller (uncredited)

Lisa Anita Wegner as Sara (uncredited)

Brad Wozny as Sailor (uncredited)

Sean Young as Parade Observer (uncredited)