David Keith as Andrew McGee

Drew Barrymore as Charlie McGee

Freddie Jones as Dr. Joseph Wanless

Heather Locklear as Vicky McGee

Martin Sheen as Captain Hollister

George C. Scott as John Rainbird

Art Carney as Irv Manders

Louise Fletcher as Norma Manders

Moses Gunn as Dr. Pynchot

Antonio Fargas as Taxi Driver

Drew Snyder as Orville Jamieson

Curtis Credel as Bates

Keith Colbert as Mayo

Dick Warlock as Knowles

Jeff Ramsey as Steinowitz

Jack Magner as Young Serviceman

Lisa Anne Barnes as Serviceman's Girlfriend

Larry Sprinkle as Security Guard

Cassandra Ward-Freeman as Woman in Stall

Scott R. Davis as Bearded Student

Nina Jones as Grad Assistant

William Alspaugh as Proprietor

Laurens Moore as Old Man

Anne Fitzgibbon as Old Lady

Steve Boles as Mailman

Stanley Mann as Motel Owner

Robert Miano as Blinded Agent

Leon Rippy as Blinded Agent

Carole Francisco as Joan Dugan

Wendy Womble as Josie

Etan Boritzer as DSI Technician

Joan Foley as DSI Technician

John Sanderford as Albright

Orwin C. Harvey as DSI Orderly

George P. Wilbur as DSI Orderly

Carey Fox as Agent Hunt

Laura Warner as Girl in Country Store (uncredited)