Dan Aykroyd as Elwood Blues

John Goodman as Mighty Mack McTeer

Joe Morton as Cab Chamberlain

Frank Oz as Warden

J. Evan Bonifant as Buster Blues

B.B. King as Malvern Gasperon

Junior Wells as Junior Wells

Willie Hall as Willie Hall

Matt Murphy as Matt 'Guitar' Murphy

Lou Marini as 'Blue Lou' Marini

Aretha Franklin as Mrs. Murphy

Donald 'Duck' Dunn as Donald 'Duck' Dunn

Steve Cropper as Steve 'The Colonel' Cropper

Tom Malone as 'Bones' Malone

Alan Rubin as 'Mr. Fabulous'

Jonny Lang as Custodian

Wilson Pickett as Mr. Pickett

Sam Moore as Reverend Morris

James Brown as Cleophus James

Paul Shaffer as Marco

Eric Clapton as The Louisiana Gator Boys

Bo Diddley as The Louisiana Gator Boys

Isaac Hayes as The Louisiana Gator Boys

Dr. John as The Louisiana Gator Boys

Lou Rawls as The Louisiana Gator Boys

Jimmie Vaughan as The Louisiana Gator Boys

Nia Peeples as Lt. Elizondo

Kim Roberts as Dancer

Erykah Badu as Queen Moussette

Max Landis as Ghostrider

Billy Preston as The Louisiana Gator Boys

Steve Winwood as The Louisiana Gator Boys

Grover Washington Jr. as The Louisiana Gator Boys

Gary U.S. Bonds as The Louisiana Gator Boys

Tommy McDonnell as The Louisiana Gator Boys

Jon Faddis as The Louisiana Gator Boys

Charlie Musselwhite as The Louisiana Gator Boys

Joshua Redman as The Louisiana Gator Boys

Travis Tritt as The Louisiana Gator Boys

Clarence Clemons as The Louisiana Gator Boys

Demo Cates as Stripster Band

Patrice Goodman as Dancer

Jack DeJohnette as The Louisiana Gator Boys

Darrell Hammond as Robertson

Slavko Hochevar as Russian thug #2

Danny Ray as Deacon

Steve Potts as Stripster Band

Nicholas Rice as County Fair Announcer