Dan Aykroyd as Elwood Blues

John Goodman as Mighty Mack McTeer

Joe Morton as Cab Chamberlain

Frank Oz as Warden

J. Evan Bonifant as Buster Blues

B.B. King as Malvern Gasperon

Wilson Pickett as Mr. Pickett

Aretha Franklin as Mrs. Murphy

James Brown as Cleophus James

Junior Wells as Junior Wells

Willie Hall as Willie Hall

Matt Murphy as Matt 'Guitar' Murphy

Lou Marini as 'Blue Lou' Marini

Donald 'Duck' Dunn as Donald 'Duck' Dunn

Steve Cropper as Steve 'The Colonel' Cropper

Tom Malone as 'Bones' Malone

Alan Rubin as 'Mr. Fabulous'

Jonny Lang as Custodian

Sam Moore as Reverend Morris

Paul Shaffer as Marco

Nia Peeples as Lt. Elizondo

Erykah Badu as Queen Moussette

Max Landis as Ghostrider

Eric Clapton as The Louisiana Gator Boys

Bo Diddley as The Louisiana Gator Boys

Isaac Hayes as The Louisiana Gator Boys

Dr. John as The Louisiana Gator Boys

Lou Rawls as The Louisiana Gator Boys

Jimmie Vaughan as The Louisiana Gator Boys

Billy Preston as The Louisiana Gator Boys

Steve Winwood as The Louisiana Gator Boys

Grover Washington Jr. as The Louisiana Gator Boys

Gary U.S. Bonds as The Louisiana Gator Boys

Tommy McDonnell as The Louisiana Gator Boys

Jon Faddis as The Louisiana Gator Boys

Charlie Musselwhite as The Louisiana Gator Boys

Joshua Redman as The Louisiana Gator Boys

Travis Tritt as The Louisiana Gator Boys

Clarence Clemons as The Louisiana Gator Boys

Jack DeJohnette as The Louisiana Gator Boys

Willie Weeks as The Louisiana Gator Boys

Koko Taylor as The Louisiana Gator Boys

Jeffrey Baxter as The Louisiana Gator Boys

Darrell Hammond as Robertson

Danny Ray as Deacon

Nicholas Rice as County Fair Announcer

Walter Levine as Same Guard

Tom Davis as Prison Clerk

Kathleen Freeman as Mother Mary Stigmata

Gloria Slade as Police Receptionist

Jennifer Irwin as Nun #1

Liz Gordon as Nun #2

Lonnie Brooks as Lonnie Brooks

Steve Potts as Stripster Band

Leon Pendarvis as Stripster Band

Demo Cates as Stripster Band

Birch Johnson as Stripster Band

Victor Pedtrchenko as Ivan

Michael Bodnar as Russian Thug #1

Slavko Hochevar as Russian Thug #2

Wally High as Russian Thug #3

Richard Kruk as Russian Thug #4

John Lyons as Russian Thug #5

George Sperdakos as Priest

Murphy Dunne as Murph

Eddie Floyd as Ed

Jillian Rees-Brown as Phone Operator (as Jillian Hart)

Steve Lawrence as Maury Sline

John Popper as Motel Band

Bobby Sheehan as Motel Band

Brendan Hill as Motel Band

Chan Kinchla as Motel Band

Susan Davy as Indiana State Trooper

Soo Garay as Indiana State Trooper

Jeff Morris as Bob

Howard Hoover as F.B.I.

Chris Marshall as Skinhead

Sandi Ross as Church Woman

Sharon Riley as Choir

Prakash John as Tent Revival Band

Fred Keeler as Tent Revival Band

Shiraz Tayyeb as Tent Revival Band

John T. Davis as Tent Revival Band

Candide Franklyn as Ton Tons Macoutes (as Candide Franklin)

Patrick Patterson as Sheriff

Shann Johnson as Matara / Dancer

Ingrid Abbott as Dancer

Ted Banfalvi as Dancer

Warren Belle as Dancer

Carla Bennett as Dancer

Denosh Bennett as Dancer

Melanie Boyko as Dancer

Patrice Goodman as Dancer

Sharon Brown as Dancer

Jenni Burke as Dancer

Kim Roberts as Dancer

Karen Burthwright as Dancer

Shawn Byfield as Dancer

Justine Campbell as Dancer

Donna Christo as Dancer

Vanessa Cobham as Dancer

Susie Dias as Dancer

Jeff Duke as Dancer

Lisa Ferguson as Dancer

Jennie Ford as Dancer

Rhett George as Dancer

Karen Holness as Dancer

Gavin Hope as Dancer

Nancy McAlear as Dancer

Marianne McCord as Dancer

Aimee McKenzie as Dancer

Christopher Medina as Dancer

Jason Meloche as Dancer

Christine Nowland as Dancer

Nicola Pantin as Dancer

Mary Paterson as Dancer

Ronnie Pulval as Dancer

Cheryl Quiacos as Dancer

Peter Radcliffe as Dancer

Simmi Raymond as Dancer

Arthur Lee Rose as Dancer

Theresa Runstedler as Dancer

Natalie Sebastien as Dancer

Jake Simons as Dancer

Richard Smith as Dancer

Louise St. Cyr as Dancer

Cherilee Taylor as Dancer

Troy Terashita as Dancer

Keri Tkacz as Dancer

Rhonda Towells as Dancer

Lena Vajakas as Dancer

Marie Ward as Dancer (as Brandi Ward)

Gina Wilkinson as Dancer

Cindy Willems as Dancer

Anna Marie Wood as Dancer

Janet Zenik as Dancer