Liam Neeson as Dr. David Marrow

Lili Taylor as Nell

Catherine Zeta-Jones as Theo

Owen Wilson as Luke Sanderson

Bruce Dern as Mr. Dudley

Marian Seldes as Mrs. Dudley

Alix Koromzay as Mary Lambetta

Todd Field as Todd Hackett

Virginia Madsen as Jane

Michael Cavanaugh as Dr. Malcolm Keogh

Tom Irwin as Lou

Charles Gunning as Hugh Crain

Saul Priever as Ritchie

M.C. Gainey as Large Man

Hadley Eure as Carolyn Crain

Kadina de Elejalde as Rene Crain

Alessandra Benjamin as Psych Patient #1

Karen S. Gregan as Psych Patient #2

Brandon Jarrett as Psych Patient #3

Mary McNeal as Psych Patient #4

William Minkin as Psych Patient #5

Debi Derryberry as Child (voice)

Jessica Evans as Child (voice)

Sherry Lynn as Child (voice)

Miles Marsico as Child (voice)

Courtland Mead as Child (voice)

Kelsey Mulrooney as Child (voice)

Kyle McDougle as Child (voice)

Hannah Swanson as Child (voice)

Travis Tedford as Child (voice) (uncredited)