Ice Cube as Darius Stone / xXx

Samuel L. Jackson as Agent Augustus Gibbons

Willem Dafoe as Gen. George Octavius Deckert

Scott Speedman as Agent Kyle Steele

Peter Strauss as President James Sandford

Xzibit as Zeke

Michael Roof as Toby Lee Shavers

Sunny Mabrey as Charlie Mayweather

Nona Gaye as Lola Jackson

John Gleeson Connolly as Lt. Alabama "Bama" Cobb

Ramon De Ocampo as Agent Meadows

Barry Sigismondi as Bull

J. Anthony Brown as Webster

Bruce Bruce as Maurice

David Rountree as Agent

Ned Schmidtke as Col. Jack Pettibone

Lisa Joyner as Field Reporter at Fire

Gina St. John as Field Reporter

Michael Don Evans as Conductor

Brian Larsen as Bridge Actor (uncredited)

Jeanne Sakata as Field Reporter

Jeffrey Moon as Soldier

Todd Louiso as Dickie Ambrose (uncredited)

Matt Gerald as Liebo

Eddy Shalita as SWAT (uncredited)

J.J. Perry as Military Police (uncredited)

Sarah Mack as Presidential Aide

James Lewis as World Leader