Cillian Murphy as John Skillpa / Emma Skillpa

Elliot Page as Maggie

Susan Sarandon as Fanny Crill

Jaimi Paige as Wanda

Josh Lucas as Officer Tom McGonigle

Virginia Newcomb as Doris

Keith Carradine as Ray Crill

Bill Pullman as Edmund French

Graham Beckel as Connor Black

Chris Carlson as Neil

Eden Bodnar as Louise Sternberg

Paul Cram as Kenny

John Paul Gamoke as Mr. Clapp

Joel Thingvall as Guy in Bar (uncredited)

Nathan Christopher as Cal