Peter Cushing as Sherlock Holmes

André Morell as Doctor Watson

Christopher Lee as Sir Henry Baskerville

Marla Landi as Cecile Stapleton

David Oxley as Sir Hugo Baskerville

Francis de Wolff as Dr. Richard Mortimer

Miles Malleson as Bishop Frankland

Ewen Solon as Stapleton

John Le Mesurier as Barrymore

Helen Goss as Mrs. Barrymore

Sam Kydd as Perkins

Michael Hawkins as Lord Caphill

Judi Moyens as Servant Girl

Michael Mulcaster as Convict

David Birks as Servant