Melissa McCarthy as Flora

Paapa Essiedu as Bernard Bottle

Denée Benton as Julie Bottle

Jordyn McIntosh as Eve Bottle

Alan Cumming as Flaxman

Marc Maron as Lenny

Tate Ellington as Johnny

LaChanze as Grandma Patty

Ellen Cleghorne as Bernard’s Mother

Oberon K.A. Adjepong as Bernard’s Father

Ego Nwodim as Diana

John Reynolds as Marvin

Nyasha Hatendi as Pete

Emanuele Secci as Henry Hackford

Luis Guzmán as Detective Perez

Savino LaQuale as Fireman

Aaron Berg as Fireman

Ralph Brown as Sorcerer

Claudia Robinson as Bernard’s Grandmother

Victoria Collett as Emma

David Moreland as Neighbor

Raymond Neil Hernandez as Hot Chocolate Man

Lyman Chen as Charles

John Cashin as Celt (uncredited)

Mark Green as Young Bernard’s Father