Jerry O'Connell as Joe

Megan Ward as Lily Dougherty

Billy West as Ralph Roach (voice)

Reginald Hudlin as Rodney Roach (voice)

Willi One Blood as Complaint Handler

Tracy Vilar as Complaint Handler

Sandra 'Pepa' Denton as Blank

Robert Vaughn as Senator Dougherty

Shiek Mahmud-Bey as Vladimir Bianco

Jon Spencer as Boss Hog Band Member

Paul Bartel as NEA Scout

Tommy Hollis as Boss Plumber

Don Ho as Alberto Bianco

Jim Sterling as Jesus Bianco / Voice of Cockroach

David Huddleston as P.I. Smith

Vincent Pastore as Apartment Broker #2

Scott Bigelow as Boss Construction

Moby as Club DeeJay

Dave Chappelle as Cockroach (voice)

Godfrey as Cockroach (voice)

Tim Blake Nelson as Cockroach (voice)

BD Wong as Cockroach (voice)

Lord Kayson as Stick-Up Man #2

Alex Molina as Stick-Up Man #3

Frank Bello as Stick-Up Man #1

Jim Turner as Walter Shit / Voice of Cockroach

Wayman Ezell as Apartment Broker #1