Michael Douglas as Dr. Nathan Conrad

Sean Bean as Patrick Koster

Brittany Murphy as Elisabeth Burrows

Skye McCole Bartusiak as Jessie Conrad

Guy Torry as Dolen

Jennifer Esposito as Det. Sandra Cassidy

Famke Janssen as Aggie Conrad

Oliver Platt as Dr. Louis Sachs

Shawn Doyle as Russel Maddox

Victor Argo as Sydney Simon

Conrad Goode as Max Dunlevy

Paul Schulze as Jake

Lance Reddick as Arnie

Aidan Devine as Leon Edward Croft

Alex Campbell as Jonathan

Philip DeWilde as Intern

Sam Montesano as Frankie

Arlene Duncan as Aide

Judy Sinclair as Zelda Sinclair

Larry Block as Doorman

David Warshofsky as Ryan

Darren Frost as Janitor

Philip Williams as Large Cop

Louis Vanaria as Cop at Scene

Daniel Kash as Detective Garcia

Lucie Laurier as Vanessa

Isabella Fink as 8-Year-Old Elisabeth

Ray Iannicelli as Man at Marina

Colm Magner as Cop #1

Cyrus Farmer as Officer #1

Martin Roach as Transit Cop

Patricia Mauceri as Sofia

Tony Bruno as Radio Host (uncredited)

Paul J.Q. Lee as Man with a Cell Phone (uncredited)

Lorli Villanueva as Chinese Woman (uncredited)