Walter Matthau as George Wilson

Mason Gamble as Dennis Mitchell

Joan Plowright as Martha Wilson

Christopher Lloyd as Switchblade Sam

Lea Thompson as Alice Mitchell

Robert Stanton as Henry Mitchell

Amy Sakasitz as Margaret Wade

Kellen Hathaway as Joey

Paul Winfield as Chief of Police

Natasha Lyonne as Polly

Devin Ratray as Mickey

Hank Johnston as Gunther

Melinda Mullins as Andrea

Billie Bird as Edith Butterwell

Bill Erwin as Edward Little

Arnold Stang as Photographer

Ben Stein as Boss

Ethel Gerstein as Gaggle Lady #1

Rebecca Hogan as Gaggle Lady #2

Leona Toppel as Gaggle Lady #3

Peggy Goldberg as Gaggle Lady #4

Jack McGuigan as Gaggle Man

Corey Vane as Mike

Casey Gamble as Hide and Seeker

Diana Rein as Babysitter

Robert A. Saunders as Broken Arm Babysitter

Beverly J. O'Donnell as Elderly Babysitter

Suzy Brack as Next-Door Neighbor (uncredited)

Thomas F. Evans as Dennis Mitchell's Neighbor (uncredited)

Kirk Kelly as Kid in Window (uncredited)

Jeannie Russell as Neighbor (uncredited)