Danny DeVito as Sam Stone

Bette Midler as Barbara Stone

Judge Reinhold as Ken Kessler

Helen Slater as Sandy Kessler

Anita Morris as Carol Dodsworth

Bill Pullman as Earl James Mott

William G. Schilling as Chief Henry Benton

Art Evans as Lt. Bender

Clarence Felder as Lt. Walters

J.E. Freeman as Bedroom Killer

Gary Riley as Heavy Metal Kid

Frank Sivero as The Mugger

Phyllis Applegate as Loan Officer

Jeannine Bisignano as Hooker in Car

J.P. Bumstead as Technician

Jon Cutler as Stereo Store Customer

Susan Marie Snyder as Stereo Store Customer

Jim Doughan as Cop at Sam's House

Christopher J. Keene as Cop at Jail

Henry Noguchi as Coroner

Arnold F. Turner as Cop with Killer Picture

Bob Tzudiker as Sam's Attorney

Charles A. Vanegas as Arresting Cop

Louise Yaffe as Social Worker

Janet Rotblatt as Secretary to Chief of Police

Charlotte Zucker as Judge

Art Bonilla as Waiter

Rick DeReyes as Newscaster

Mie Hunt as Newscaster

Ron Tank as Newscaster

Susan Stadner as Aerobic Instructor

Beth R. Johnson as Aerobic Instructor

Twyla Littleton as Model

Mary Elizabeth Thompson as Elderly Woman

Phil Hartman as Newsreader (voice) (uncredited)