Luke Wilson as Wendell Baker

Eva Mendes as Doreen

Jacob Vargas as Reyes Morales

Owen Wilson as Neil King

Harry Dean Stanton as Skip Summers

Kris Kristofferson as L.R. Nasher

Seymour Cassel as Boyd Fullbright

Eddie Griffin as McTeague

Will Ferrell as Dave

Angela Alvarado as Irma

Jo Harvey Allen as Wanda King

Buck Taylor as Bob Draper

Billy Joe Shaver as Reverend Shackelton

Azura Skye as May

Nicole Swahn as Lucy

Heather Kafka as Marianne

Richard Andrew Jones as Dr. Van Horn

Steve Stodghill as Otto Brinker

Mark Wallace as Federale Officer

Raymond Gestaut as Sonny Sr.

Dennis Williams as Leon

Spencer Scott as Grady

Glen Powell as Paper Boy

Joel Trevino as Teo Torres

James Coolidge as Oliver Torres

Mac Davis as Agent Buck

John Wirt as Shouting Guard

Mike Ritchey as Bus Guard

Lucina Paquet as Mrs. Ogelsby

Charles Sanders as Vittorio Infante

Randy Stripling as Mr. Montoya

Robert Musgrave as Motorcycle Cop

Brady Coleman as Lawyer #1

Paul Wright as Lawyer #2

C. Anthony Jackson as Nurse Turner

Grover Coulson as Nurse Percy

Grant James as Mr. Baird

Phyllis Browne as Betty

Dudley Browne as Clark

Mathew Greer as Eugene

Brad Arrington as Dr. Crane

Mark Seliger as Cliff Taggert

Abel Pastor as Older Mexican Man

Matt Hensarling as Gary

Garry Peters as Fed #1

Marco Perella as Investigator

Jesus F. Tellez as Mexican Father

Ashley Andersen as Captain Andersen

Isis Stephanie Cerda as Flower Girl

Raul V. Carrera as Younger Mexican Man

John C. Wells as Frat Boy

Brother as Junior