Milo Ventimiglia as Ted Grey

Alyssa Milano as Gwen Williamson

Michael Weston as Jake Gallo

Lauren Lee Smith as Juliette Bath

Johnny Whitworth as Griffin Cavenaugh

John de Lancie as Dr. Quentin Morris

Meiling Melançon as Catherine Ivy

Keir O'Donnell as Ben Stravinsky

Buddy Lewis as Harper Johnson

Dan Callahan as Chip Bentwood

Larry Drake as Fat Bastard

Med Abrous as Young Pathology Resident

Alan Blumenfeld as Mr. Williamson

Gary Buckner as Motherfucker

Jeb Burris as Worker

Eurydice Davis as Hooker

Jarvis W. George as ICU Doctor

Anne Girard as Donna

Eric Kaldor as Homeless Lunatic

Keith Morris as Hitchhiker

Kate Mulligan as Woman on Bus

Donnie Smith as Man on Bus

Yvonne Mojica-Nelson as Hispanic ICU Nurse

Debbie Pollack as Mrs. Williamson

Cheryl Starbuck as Panicked Woman

Sam Witwer as Party Boy

Brett Kelly as Dead Kid

Waneeki Yokomee-Fung as Visitor