Michael Caine as Sherlock Holmes

Ben Kingsley as Dr. John Watson

Jeffrey Jones as Inspector Lestrade

Lysette Anthony as Impostor Leslie Giles

Nigel Davenport as Lord Smithwick

Peter Cook as Greenhough

Gregor Fisher as Bobby at Warehouse

Paul Freeman as Prof. James Moriarty

George Sweeney as John Clay

John Tordoff as Mr. Andrews

Alexandra Spencer as Mrs. Andrews

Matthew Sim as Real Lesley

Pat Keen as Mrs. Hudson

Matthew Savage as Wiggins

Tim Killick as Sebastian

John Warner as Peter Giles

Harold Innocent as Mayor Johnson

Murray Ewan as Archie

Stephen Tiller as Reporter #1

Michael O'Hagan as Reporter #2

Ivor Roberts as Reporter #3

Martin Pallot as Photographer

Caroline Milmoe as Constance

Steven O'Donnell as Bartender

James Bree as Barrister

Clive Mantle as Thug #1

Dave Cooper as Thug #2

Andy Bradford as Dockworker

Jennifer Guy as Christabel

Elizabeth Kelly as Landlady

Lesley Daine as Lady on Train

John Surman as Constable at Lakes