John Cusack as Nick Falzone

Billy Bob Thornton as Russell Bell

Cate Blanchett as Connie Falzone

Angelina Jolie as Mary Bell

Gene Dinovi as Enzo Sorrento

Vicki Lewis as Tina Leary

Kurt Fuller as Ed Clabes

Jake Weber as Barry Plotkin

Matt Ross as Ron Hewitt

Mike O'Malley as Pete

John Carroll Lynch as Doctor Freeze

Catherine Lloyd Burns as Tanya Hewitt

Sarah Knowlton as Beverly

Molly Price as Crystal Plotkin

Kiersten Warren as Karen

Amanda Delaney as Bodybuilder

Ramona Milano as TV Reporter

Jenny Parsons as Flight Attendant

Robyn Stevan as Sara

Martin Roach as Pilot (voice)