Julia Roberts as Alma Imhoff

Ayo Edebiri as Maggie Resnick

Andrew Garfield as Hank Gibson

Chloë Sevigny as Dr. Kim Sayers

Michael Stuhlbarg as Frederik Imhoff

Thaddea Graham as Katie

Will Price as Arthur

Christine Dye as Patricia

Lio Mehiel as Alex

David Leiber as Dean RJ Thomas

Lailani Olan as Faviola

Nora Garrett as Billie

Frankie Ferrari as Wendy / Kim's Secretary / Pharmacy Tech

Burgess Byrd as Daphne Walgreens

Sadie Scott as Protestor

Ariyan Kassam as Peter