Bob Hope as Dan Bartlett

Eva Marie Saint as Sheila Bartlett

Ralph Bellamy as John Ed

Forrest Tucker as Reese

Anne Archer as Crazy Hollister

Keenan Wynn as Sheriff 'Houndtooth' Riley

Henry Darrow as Joe Little Cloud

Chief Dan George as Old Bear

Doodles Weaver as Cactus, Deputy Sheriff

Pat Morita as Yamamoto

Richard Yniguez as Motorcyclist

Johnny Carson as Himself (uncredited)

Bing Crosby as Himself (uncredited)

John Wayne as Himself (uncredited)

Betty Ann Carr as Mary Little Cloud

Flip Wilson as Flip Wilson (uncredited)

Herb Vigran as Roscoe Snagby

Gordon Oliver as Mr. Willie Sparker

Isabella Hoopes as Elderly Lady

Buster Shaver as Doc Morton

Tracy Bogart as Teenage Girl

Trudy Bordoff as Teenage Girl

Priscilla Garcia as Motorcyclist

Paul Bogart as Dr. Kaufman (uncredited)