Olivia Colman as Ivy Rose

Benedict Cumberbatch as Theo Rose

Andy Samberg as Barry

Kate McKinnon as Amy

Belinda Bromilow as Janice

Ncuti Gatwa as Jeffrey

Sunita Mani as Jane

Zoë Chao as Sally

Jamie Demetriou as Rory

Allison Janney as Eleanor

Delaney Quinn as Hattie Rose (Younger)

Ollie Robinson as Roy Rose (Younger)

Hala Finley as Hattie Rose (Older)

Wells Rappaport as Roy Rose (Older)

Will Smith as Derek

Caroline Partridge as Sylvia (Food Critic)

Margaret Clunie as Sophy

Ollie Dabbous as Himself

Jude Coward Nicoll as Teenager on Airplane

Akie Kotabe as Alan

Emily Piggford as Lily

Paul Pape as Commercial Announcer

Ranjani Brow as News Anchor

Robin Atkin Downes as Boss

Matt Corboy as HAL (voice)