Olivia Colman as Ivy Rose

Benedict Cumberbatch as Theo Rose

Kate McKinnon as Amy

Andy Samberg as Barry

Ncuti Gatwa as Jeffrey

Sunita Mani as Jane

Zoë Chao as Sally

Jamie Demetriou as Rory

Delaney Quinn as Hattie Rose - Younger

Hala Finley as Hattie Rose - Older

Ollie Robinson as Roy Rose - Younger

Wells Rappaport as Roy Rose - Older

Allison Janney as Eleanor

Will Smith as Derek

Caroline Partridge as Sylvia - Food Critic

Margaret Clunie as Sophy

Ollie Dabbous as Ollie Dabbous

Jude Coward Nicoll as Teenager on Airplane

Belinda Bromilow as Janice

Akie Kotabe as Alan

Emily Piggford as Lily

Paul Pape as Commercial Announcer

Ranjani Brow as News Anchor

Robin Atkin Downes as Boss

Matt Corboy as HAL (voice)

Lauren Beacham as Barbecue Guest (uncredited)