Keith David as Narrator (voice)

Kevin Conway as Mark Twain (voice)

Blythe Danner as Olivia "Livy" Langdon Clemens (voice)

Philip Bosco as (voice)

Tim Clark as (voice)

Carolyn McCormick as (voice)

Amy Madigan as (voice)

Cynthia Nixon as (voice)

John Boyer as Self (uncredited)

Jocelyn Chadwick as Self (uncredited)

Shelly Fisher Fishkin as Self (uncredited)

Dick Gregory as Self (uncredited)

Hal Holbrook as Self (uncredited)

Arthur Miller as Self (uncredited)

Chuck Jones as Self (uncredited)

Ron Powers as Self (uncredited)

Laura Skandera-Trombley as Self (uncredited)

William Styron as Self (uncredited)