Alejandro Jodorowsky as El Topo

Brontis Jodorowsky as Son of El Topo

Mara Lorenzio as Marah / The Woman

David Silva as The Colonel

Paula Romo as Desconocida

Jacqueline Luis as Mujercita

Robert John as Adult Son of El Topo

Héctor Martínez as Maestro 1

Juan José Gurrola as Maestro 2

Víctor Fosado as Maestro 3

Agustín Isunza as Maestro 4

José Legarreta as Dying Man

Ignacio Martínez España as Armless Man

Eliseo Gardea Saucedo as Legless Man

Alfonso Arau as Bandit 1

José Luis Fernández as Bandit 2

Ali Junco as Bandit 3

Gerardo Zepeda as Bandit 4

René Barrera as Bandit 5

René Alís as Bandit 6

Federico Gonzáles as Bandit 7

Vicente Lara as Bandit 8

Pablo Leder as Monk 1

Giuliano Girini Sasseroli as Monk 2

Cristian Merkel as Monk 3

Aldo Grumelli as Monk 4

Bertha Lomelí as Gitana

Carlos Lavenant as Verdugo 1

Eliseo Pereda as Verdugo 2

Pablo Marichal as Esclavo

Beatriz Beltrán Lobo as Señora 1

Carmen Lamadrid as Señora 2

Pepita González as Señora 3

Cecilia Leger as Señora 4

Elvira Agosti as Señora 5

Antonio Álvarez as Prisonero 1

Rubén C. González as Prisonero 2

Víctor Manuel Osorio as Prisonero 3

José Pérez Bustos as Prisonero 4

Eduardo Danel as Prisonero 5

Álvaro García as Prisonero 6

José Antonio Alcaraz as Sheriff

Felipe Díaz Garza as Ayudante

Patricio Pereda as Niño

Marcos E. Contreras as Boxeador 1

Arturo Silva as Boxeador 2

Julián de Meriche as Cura

Valerie Jodorowsky as Mujer Iglesia

José Luis González de León as Hombre Iglesia

Francisco González Salazar as Tendero

Pedro García as Hombre Zanahoria