Dana Snyder as Master Shake (voice)

Carey Means as Frylock (voice)

Dave Willis as Meatwad / Carl / Ignignokt / Video Game Voice (voice)

Andy Merrill as Oglethorpe (voice)

Bruce Campbell as Chicken Bittle (voice)

Fred Armisen as Time Lincoln (voice)

Chris Kattan as Walter Melon (voice)

Matt Maiellaro as Err / Cybernetic Ghost / Satan (voice)

Mike Schatz as Emory (voice)

C. Martin Croker as Dr. Weird / Steve (voice)

Neil Peart as Neil Peart of Rush (voice)

MC Chris as MC Pee Pants (voice)

George Lowe as Space Ghost (voice)

Isaac Hayes III as Plantation Owner (voice)

Tina Fey as Nine-Layer Bean Burrito (voice)

H. Jon Benjamin as CIA Agent 1 (voice)

Jon Glaser as CIA Agent 2 (voice)

Craig Hartin as Rob Goldstein (voice)

Matt Harrigan as Linda (voice)